Matthew McConaughey Joseph "Coop" Cooper Anne Hathaway Dr. Amelia Brand Jessica Chastain Murphy "Murph" Cooper Michael Caine Professor John Brand Bill Irwin TARS (voice) Ellen Burstyn Old Murph Mackenzie Foy Young Murph Casey Affleck Tom Cooper John Lithgow Donald Wes Bentley Doyle David Gyasi Romilly Matt Damon Mann Topher Grace Getty Timothée Chalamet Young Tom David Oyelowo School Principal William Devane Williams Josh Stewart CASE (voice) Collette Wolfe Ms. Hanley Leah Cairns Lois Russ Fega Crew Chief Lena Georgas Nurse Practitioner Jeff Hephner Doctor Elyes Gabel Administrator Brooke Smith Nurse Liam Dickinson Coop Francis X. McCarthy Boots Andrew Borba Smith Flora Nolan Girl on Truck Kristian Van der Heyden Scientist (uncredited) Joseph Oliveira Astronaut (uncredited) Alexander Michael Helisek Construction Boss (uncredited) Benjamin Hardy NASA Scientist (uncredited) Matthew McConaughey Joseph "Coop" Cooper Anne Hathaway Dr. Amelia Brand Jessica Chastain Murphy "Murph" Cooper Michael Caine Professor John Brand Bill Irwin TARS (voice) Ellen Burstyn Old Murph Mackenzie Foy Young Murph Casey Affleck Tom Cooper John Lithgow Donald Wes Bentley Doyle David Gyasi Romilly Matt Damon Mann Topher Grace Getty Timothée Chalamet Young Tom David Oyelowo School Principal William Devane Williams Josh Stewart CASE (voice) Collette Wolfe Ms. Hanley Leah Cairns Lois Russ Fega Crew Chief Lena Georgas Nurse Practitioner Jeff Hephner Doctor Elyes Gabel Administrator Brooke Smith Nurse Liam Dickinson Coop Francis X. McCarthy Boots Andrew Borba Smith Flora Nolan Girl on Truck Kristian Van der Heyden Scientist (uncredited) Joseph Oliveira Astronaut (uncredited) Alexander Michael Helisek Construction Boss (uncredited) Benjamin Hardy NASA Scientist (uncredited)