Leonardo DiCaprio Ernest Burkhart Lily Gladstone Mollie Burkhart Robert De Niro William Hale Jesse Plemons Tom White Scott Shepherd Byron Burkhart Cara Jade Myers Anna JaNae Collins Reta William Belleau Henry Roan Jason Isbell Bill Smith Louis Cancelmi Kelsie Morrison John Lithgow Prosecutor Peter Leaward Tantoo Cardinal Lizzie Q Jillian Dion Minnie Brendan Fraser W.S. Hamilton Tatanka Means John Wren Tommy Schultz Blackie Thompson Sturgill Simpson Henry Grammer Ty Mitchell John Ramsey Gary Basaraba Detective Burns Charlie Musselwhite Alvin Reynolds Pat Healy Agent John Burger Steve Witting Dr. James Shoun Steve Routman Dr. David Shoun Gene Jones Pitts Beatty Michael Abbott Jr. Agent Frank Smith J.C. MacKenzie Radio Announcer Jack White Radio Show Actor Larry Sellers Non-Hon-Zhin-Ga Barry Corbin Undertaker Turton Gabriel Casdorph Agent Joe Jones Samuel French Agent CJ Robinson Randy Houser Scott Mathis Eric Parkinson Deputy Marshal Jay Paulson Car Salesman Lee Eddy Mrs. Mackie